A diffusion‐based neurite length‐sensing mechanism involved in neuronal symmetry breaking
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چکیده
منابع مشابه
A diffusion-based neurite length-sensing mechanism involved in neuronal symmetry breaking
Although there has been significant progress in understanding the molecular signals that change cell morphology, mechanisms that cells use to monitor their size and length to regulate their morphology remain elusive. Previous studies suggest that polarizing cultured hippocampal neurons can sense neurite length, identify the longest neurite, and induce its subsequent outgrowth for axonogenesis. ...
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As neurons develop, several immature processes (i.e., neurites) grow out of the cell body. Over time, each neuron breaks symmetry when only one of its neurites grows much longer than the rest, becoming an axon. This symmetry breaking is an important step in neurodevelopment, and aberrant symmetry breaking is associated with several neuropsychiatric diseases, including schizophrenia and autism. ...
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A. Veglio, 2 A. Gamba, 2 M. Nicodemi, F. Bussolino, and G. Serini Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo (TO), Italy. CNISM, Corso Duca degli Abruzzi 24, 10125 Torino, Italy. Politecnico di Torino, Corso Duca degli Abruzzi 24, 10125 Torino, Italy; and INFN Torino, I...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2010
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2010.51